Webinar: Prof. Alejandro Frangi - Primum Non Nocere, Secundum Simulare: The imperatives of in silico evidence in the digital era

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In silico trials (ISTs) and computational medicine are poised to transform medical device development and regulation, embodying the principle of “Do No Harm by Design”. This talk explores how ISTs can address the limitations of traditional clinical trials, including high costs, lengthy timelines, and safety concerns. By simulating device performance in virtual environments, ISTs offer a pathway to accelerate innovation, reduce expenses, and enhance patient safety. We’ll examine compelling examples demonstrating ISTs’ ability to replicate and extend traditional trial insights, tackling challenges like off-label use, device-dependent healthcare inequities, and optimal treatment stratification. Emphasising collaboration between regulators, industry, and patients, we’ll discuss how ISTs can foster safer, more sustainable medical innovation.

Speaker:

Professor Alejandro Frangi FREng FIEEE, a leader in computational medicine and in silico trials, holds the Bicentennial Turing Chair in Computational Medicine at the University of Manchester. As Director of the Christabel Pankhurst Institute, he accelerates health tech innovation translation in Greater Manchester. Prof Frangi leads the UK Centre of Excellence on in-silico Regulatory Science and Innovation and the InSilicoUK Pro Innovation Regulations Network (www.insilicouk.org), advancing in silico medicine nationally. His research focuses on AI and in silico technologies, fostering collaboration between academia, industry, and regulators to drive healthcare innovation. He works at the intersection of computational modelling and medical science and aims to revolutionise patient care through cutting-edge technologies and interdisciplinary approaches. Prof Frangi is also committed to disseminating the benefits of in silico technologies to the lay audience through his recently launched podcast, In Silico Trials, Real Impacts (insilicouk.podbean.com).