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Core Outcome Sets

A core outcome set (COS) is an agreed standardized set of outcomes that should be measured and reported in all studies of a specific health condition or intervention. A COS is developed using a systematic and transparent process that involves input from key stakeholders, such as patients, healthcare professionals, and researchers.

The purpose of a COS is to ensure that all studies of a particular health condition or intervention measure and report on the most important outcomes in a consistent way. This can help to ensure that the results of different studies can be compared and combined in a meaningful way, which can help to improve the overall quality of research in a particular area.

A COS can include a range of outcomes, such as clinical outcomes (e.g. survival, disease progression), patient-reported outcomes (e.g. quality of life, symptom severity), and economic outcomes (e.g. cost-effectiveness). The specific outcomes included in a COS will depend on the condition or intervention being studied, as well as the priorities and preferences of the stakeholders (including patients) involved in the development process.

Below is a list of HRB-TMRN COS funded and / or led by HRB members. A full listing of published COS can be accessed via the COMET initiative website. https://www.comet-initiative.org/

ObjectiveTitle
2022COSUTI: a core outcome set for the effectiveness of treatment interventions for uncomplicated urinary tract infections (UTIs) in adults.Prof Declan Devane, Dr Claire Beecher, Dr Sinead Duane, Prof Andrew Murphy, Dr Patricia Healy, Dr Akke Vellinga, Prof Martin Cormican, Dr Andrew Smyth (University of Galway)view
2022Multi-Round compared to Real-Time Delphi for consensus in core outcome set (COS) development: a randomised trial.Dr Fiona Quirke (University of Galway), Dr Patricia Healy (University of Galway), Dr Linda Biesty (University of Galway), Prof Eleanor Molloy (Trinity College Dublin), Prof Declan Devane (University of Galway),view
2020A core outcome set for studies of gestational diabetes mellitus prevention and treatment.Dr Aoife Egan (University of Galway), Prof Valerie Smith (TCD), Prof Declan Devane, Dr Linda Biesty, Prof Fidelma Dunne (University of Galway)view
2020Salutogenic Intrapartum Core Outcomes (SIPCO): Identification of a minimum dataset using an international eDelphi consensus process.Prof Declan Devane (Unviersity of Galway), Prof Valerie Smith, Prof Deirdre Daly, Prof Cecily Begley (Trinity College Dublin)view
2020Core outcomes in neurorehabilitation: development of a core outcome set for acquired brain injury.Prof Dominic Trepel (Trinity College Dublin)view
2020Follow-up at 1 year and beyond of women with gestational diabetes treated with insulin and/or oral glucose-lowering agents: a core outcome set using a Delphi surveyDr Aoife Egan, Prof Declan Devane, Dr Linda Biesty, Prof Fidelma Dunne (University of Galway)view
2019A core outcome set for trials of infant-feeding interventions to prevent childhood obesity.Dr Karen Matvienko-Sikar, Ciara Griffin, Niamh McGrath (UCC), Dr Elaine Toomey (University of Galway), Molly Byrne, Colette Kelly, Caroline Heary, Prof Declan Devane (University of Galway), Prof Patricia M Kearney (UCC)view
2019A core outcome set for randomised trials evaluating interventions for treatment of pregnant women with pregestational diabetes.Dr Aoife Egan, Dr Linda Biesty, Prof Paddy Gillespie, Prof Fidelma Dunne, Prof Declan Devane (Unviersity of Galway),view
2019The development of a core outcome set for interventions in the treatment of uncomplicated urinary tract infections (UTI’s) in adult patients.Prof Declan Devane, Dr Claire Beecher, Dr Sinead Duane, Prof Andrew Murphy, Dr Patricia Healy, Dr Akke Vellinga, Prof Martin Cormican, Dr Andrew Smyth (University of Galway)view
2019Developing a core outcome set (COS) for clinical trials on interventions for the detection and management of reduced fetal movements in pregnancy.Prof Valerie Smith (Trinity College Dublin), Prof Declan Devane (Unversity of Galway).view
2019A Core Outcome Set for the prevention and treatment of fetal GROwth restriction: deVeloping Endpoints: the COSGROVE study.Dr Patricia Healy, Prof Declan Devane (University of Galway)view
2018Core outcome sets for prevention and treatment of postpartum haemorrhage: an international Delphi consensus study.Prof Declan Devane (Unviersity of Galway)view
2018Development of a core outcome set for trials on induction of labour (COSIOL): An international multi-stakeholder Delphi study.Prof Declan Devane (University of Galway)view
2018COHESION: Core Outcomes in Neonatal Encephalopathy.Dr Fiona Quirke (University of Galway), Dr Patricia Healy (University of Galway), Dr Linda Biesty (University of Galway), Prof Eleanor Molloy (Trinity College Dublin), Prof Declan Devane (University of Galway),view
2018Developing a Core Outcome Set for Childhood Obesity Prevention: A Systematic Review.Dr Karen Matvienko-Sikar, Ciara Griffin, Niamh McGrath (UCC), Dr Elaine Toomey (University of Galway), Molly Byrne, Colette Kelly, Caroline Heary, Prof Declan Devane (University of Galway), Prof Patricia M Kearney (UCC)view
2017A core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes.Dr Aoife Egan (University of Galway), Prof Valerie Smith (TCD), Prof Declan Devane (University of Galway), Prof Fidelma Dunne (University of Galway)view
2017A core outcome set for adult cardiac surgery trials: A consensus study.Prof Declan Devane (University of Galway)view
2016Developing a core outcome set (COS) for intrapartum fetal assessment.Prof Declan Devane (University of Galway), Prof Valerie Smith (Trinity College Dublin), Prof Geraldine Boylan (Unviersity College Cork),view
2016Core Outcome Set-STAndards for Reporting: The COS-STAR Statement.Prof Declan Devane (University of Galway)view
2015Heterogeneity of wound outcome measures in RCTs of treatments for VLUs: a systematic review.Prof Georgina Gethin, Prof Decaln Devane (University of Galway)view

Core Outcome Set (COS) Funding

In 2023 the network will provide funding for one COS award. This award is worth up to €10,000 (25% institutional overheads of direct project costs also available) and will provide funding to explore the need for a COS within any health related area or assist in the development of an ongoing COS for which no funding is available.

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