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Welcome to the HRB Trials Methodology Research Network

The HRB-Trials Methodology Research Network (HRB-TMRN) is a collaborative initiative between a number of Irish and international higher education institutes and methodology centers.
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What is the HRB-TMRN?

The HRB-Trials Methodology Research Network (HRB-TMRN) is a collaborative initiative between several Irish and international higher education institutes and methodology centres.

We want to strengthen the methodology and reporting of trials in health and social care in Ireland so that they become more relevant, accessible and influential for our community of patients and other service users, practitioners, policymakers and the public. This is achieved through a programme of work relating to the methodology of trials and focused on (i) support, (ii) training and education, (iii) research and innovation and (iv) Public and Patient Involvement and Engagement.

Powerful words from Noreen Doyle @DoyleNordoyle - sharing her experience of how including her son on a cancer trial delivered benefits in treatment and recovery for her daughter and so many other children confronted with the same condition just a few years later. #ResearchEthics

“Participation in international trials allows pregnant women in Ireland to access new medications and technologies earlier ” - just one of the benefits set out by @FidelmaDunne of confronting ethical dilemmas to include pregnant women in diabetes trials. #ResearchEthics

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Our Expertise

Our Network is connected to over 70 national and international trials and trials methodology organisations. We are a partner within the MRC-NIHR-Trials Methodology Research Partnership in the UK. Our collaborations give us access to world leaders in trials methodology research.

Our trials methodology research expertise includes:

Studies within a Trial (SWAT)

A SWAT is an embedded methodology research study within a planned or ongoing trial. We have been involved in SWATS for over 10 years and were involved in the first registered SWAT and we provide annual competitive funding for SWATs. Our members are active in developing and implementing SWATs across a variety of clinical trials nationally and internationally.

Core Outcome Set Development

A core outcome set is agreed, standardised set of outcomes that should be measured and reported in all trials for a specific clinical area. We have been involved in developing core outcome sets across a range of clinical areas. We are proud to collaborate with the COMET Initiative in many of these.

Priority Setting

Priority Setting Partnerships (PSPs) enable clinicians, patients and carers to work together to identify and prioritise evidence uncertainties in particular areas of health and care that could be answered by research.We have led or contributed to research agenda setting across a range of trials methodology topics and also promoted the use of prioritisation setting across clinical trial areas nationally.

Qualitative Research in Trials Methodology

We have specialized expertise in qualitative research in our Qualitative Research in Trials Centre (@QUESTSCentre). Here a team of advisors with expertise in case study research, ethnography, grounded theory, phenomenology and qualitative evidence synthesis are active in a wide range of trials methodology projects.

Latest Events

december 2023

12dec11:00 am12:00 pmTMRP Webinar: Cydney Bruce – Randomisation: Current practice for method selection

january 2024

16jan11:00 am12:00 pmTMRP Webinar: Sandra Eldridge – The INCLUDED project

18jan1:00 pm2:00 pmWebinar: Dr Suzie Cro – How to start a conversation with public partners about estimands: a practical tool

february 2024

08feb1:00 pm2:00 pmWebinar: William Cragg – Managing “participation changes” in trials: reflecting on the PeRSEVERE principles and what might come next

14feb11:00 am12:00 pmTMRP Webinar: Speakers from The Global Health Network Mesh Community of Practice – Engaging non-researchers with clinical trials

19febAll Day21Independent Data Monitoring Committee Course

Our Ethos

Collaboration & innovation

We work collaboratively and innovatively. Our doors are always open to new ideas in Trials methodology.


Involvement of all key stakeholders including patients and the public is central to what we do. This helps us ensure our work will matter most and achieve impact.


Capacity-building is central to all our work. This is essential to provide opportunity, invigorate perspective and build our research future.

Our Network operates across five University Partners,
each leading the way in trials methodology research and training