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HRB-TMRN & UL Webinar: Sequential Multiple Randomised Trial (SMART) Design

This webinar offered a brief introduction to the sequential, multiple, assignment, randomized trial (SMART) design. SMART designs are motivated by interest in tailored, sequential interventions or adaptive interventions and may be implemented to find effective strategies in intervention development. An overview of SMART design principles and introduction to analytic methods was provided, with real examples from a variety of fields. The use of the SMART design in a HRB-funded DIFA project was also outlined. This webinar was geared toward a diverse audience from scientific investigators to statisticians to students.


Dr Sara Hayes, Associate Professor in Physiotherapy at University of Limerick, is PI of a HRB-funded SMART, using the SMART design to develop an adaptive intervention to promote increase physical activity in people after stroke.

Prof. Kelley Kidwell, Associate Professor, Biostatistics, University of Michigan, is a leading international researcher in the area of SMART designs. Her methodological work centers on better matching the way in which we practice medicine and public health to the way in which we experimentally study it. Dr. Kidwell’s methods work has primarily focused on the design and analysis of sequential, multiple assignment, randomized trials (SMARTs), in standard or large size trials for treating common diseases and disorders, and in small samples or for treating rare diseases.

Prof. Cathal Walsh, Professor of Statistics, University of Limerick, is the lead statistician on a HRB-funded SMART and has been working in Medical Statistics for over two decades, and works with the Cochrane Collaboration, the National Centre for Pharmacoeconomics and researchers in hospitals and health related disciplines across the world.

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