Current Projects

PhD Projects

Methods Of Dissemination Of Research Evidence 2015 - 2018
This research is being carried out by NUI Galway PhD Student Aislinn Conway and involves collaboration with the Medical Research Council (MRC, UK) Hubs for Trials Methodology Research and the multi-national DECIDE project.
Risk-Adopted Approaches To Clinical Trial Monitoring 2015 - 2018
Background: In 2012, the Health Research Board (HRB) established a number of Clinical Research Facilities (CRF) in Irish universities. Since then, Irish universities such as University College Cork (UCC) has assumed the role of study sponsor for academic clinical trials. Under the EU’s Clinical Trial Directive 2001/20/EC, study sponsors such as UCC must ensure that trials are adequately monitored.
Barriers and facilitators to statistical rigour in academic-led clinical trial design, conduct, monitoring, analysis, reporting and dissemination of findings 2015 - 2018
The focus of this PhD research is on understanding the roles and responsibilities of statisticians, their involvement in academic and industry-led clinical trials and their collaborations with clinicians, scientists and other key clinical research members.
The Role of Context in the Implementation of Healthcare Interventions 2015 - 2018
Jessica O' Dowd (TCD) is exploring the role of context and how it affects implementation. This project is using a realist methodology in the form of a realist evaluation to explore how context affects mechanisms and outcomes in complex healthcare interventions.

Study within a Trial (SWAT)

SWAT 14: A web-based multimedia information resource on recruitment and retention of general practitioners
Recruitment in Primary Care Recruiting clinicians and patient participants to trials is recognised as a significant challenge. It is estimated that less than 50% of trials meet their target or do so with an extension to the trial length.
SWAT 11: Monitoring consent forms by Skype video-conferences
Randomised trial of Skype-based tele-monitoring versus standard monitoring This research will evaluate Skype-based monitoring versus traditional site visit monitoring within a large international clinical trial which aims to prevent stroke and coronary events.
The influence of different healthcare professionals delivering an intervention in a medication optimisation trial.
Two previous studies by our research group showed there was disparity in recommendation uptake rates between physicians and pharmacists. The objective of this SWAT is, if in a medication optimistion trial, there is a difference in recommendation uptake rates between a pharmacist delivered intervention and a physician delivered intervention. There will be a qualitative aspect to the study at then end to attempt to explain any differences observed if any.
SWAT 46: Participants' perspectives and preferences on clinical trial result dissemination
Dissemination of the results from randomised trials has traditionally been limited to three channels: scientific meetings and journals, lay media and groups with a particular health interest. To ensure that the dissemination report is clear, simple and tailored for TRUST participants, a qualitative focus group study is to be conducted with participants to elicit their perspectives, preferences and knowledge requirements.
Statistical methods for compensating for missing longitudinal data in a cluster-randomised trial
The objectives of the study are:
1) To compare Multiple Imputation (MI) with Maximum Likelihood (ML) modelling methods to compensate for loss to follow-up over time in a longitudinal, cluster-randomised trial.
2) To investigate the relative power and type I error rate of MI versus ML methods to compensate for missing data in a simulated longitudinal, cluster-randomised trial.
SWAT 6: Using a limited number of practitioners to recruit participants to a multicentre randomized trial
A key challenge in doing multicentre trials is that there is significant uncertainty about the best way to ensure good recruitment rates at different sites. Maintaining the interest of those responsible for recruiting participants can be a significant challenge and can slow the recruitment of new participants.
SWAT 15: Video presentation of trial information to potential patient participants in a randomized trial
To evaluate the effectiveness of hand-held video presentation of trial information to potential patient participants on recruitment and retention to a randomised trial.
SWAT 38: Cost implications of conducting a risk assessment prior to developing a monitoring plan for a multicentre clinical trial
Assess the cost implications of conducting a risk assessment prior to developing a monitoring plan for a multi-centre clinical trial, and examine if sites that conducted a risk assessment prior to developing their monitoring plan have less protocol violations compared to the sites that did not conduct a prior risk assessment.

Core Outcome Sets

Developing a core outcome set (COS) for clinical studies of prepregnancy care for women with pregestational diabetes mellitus.
The aim of this study was to develop a core outcome set (COS) for trials and other studies evaluating the effectiveness of prepregnancy care for women with pregestational (pre-existing) diabetes mellitus.
Developing a core outcome set (COS) for clinical trials in intrauterine growth restriction
Developing a COS for use in all studies of the screening, prevention and treatment of intrauterine growth restriction is timely and important.
Developing a core outcome set (COS) for intrapartum fetal assessment
Developing a COS for use in all studies of interventions for assessment of fetal wellbeing in labour is timely and important. The use of the COS as a minimum across the field of intrapartum fetal assessment would allow for the results of trials and other studies to be effectively compared, contrasted and combined, as appropriate.
Salutogenic Intrapartum Core Outcomes (SIPCO): Identification of a minimum dataset using an international eDelphi consensus process
Using a list of salutogenically-focused reported outcomes identified in a systematic review of systematic reviews of intrapartum interventions, conducted by the principal investigators to the project, and others, we propose to develop, through expert opinion and consensus, a set of salutogenic intrapartum core outcomes (SIPCO) for use in maternity care research and daily practice.
Developing a core outcome set (COS) for clinical trials in GDM
The majority of clinical trials in gestational diabetes mellitus (GDM) have been published in the last ten years suggesting a growing interest in research on this important topic. However, prioritization of outcomes for use in studies on GDM has been confined to medication or birth management. For this reason, developing a COS for use in all studies of the screening, prevention and treatment of GDM is timely and important.
Developing a core outcome set (COS) for clinical trials on interventions for the detection and management of reduced fetal movements in pregnancy
In recent years there has been a renewed interest in the topic of fetal movements in pregnancy, with numerous studies on aspects of both the detection and management of RFM in pregnancy appearing in the literature, including associated calls for larger randomised trials.
The development of a core outcome set for interventions in the treatment of uncomplicated urinary tract infections (UTI’s) in adult patients.
In order to address the inappropriate use of antimicrobials in the treatment of uncomplicated UTIs in primary care, further research needs to be undertaken in this area. However, inconsistency in the choice of outcomes reported have resulted in substantial challenges in synthesising evidence, ultimately limiting the capability to influence practice and policy
Core Outcome Sets for Prevention and Treatment of Postpartum Haemorrhage
Postpartum Haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Interventions for its prevention and treatment have been the subject of a large number of trials, but evidence is difficult to interpret due to heterogeneity in endpoints. We propose the development of Core Outcomes Sets (COS) for (1) prevention and (2) treatment of PPH by consulting relevant stakeholders using a Delphi survey.

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