Webinar (TMRP): Dr Kerry Dwan & Prof. Carrol Gamble - Outcome Reporting Bias and Statistical Analysis Plans in Clinical Trials

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TMRP webinar – presented by Dr Kerry Dwan (Liverpool School of Tropical Medicine), Professor Car on behalf of the MRC HTMR

Study publication bias and outcome reporting bias have been recognised as a potential threat to the validity of meta-analysis and can make the readily available evidence unreliable for decision making. Statistical Analysis Plans have the potential to reduce outcome reporting bias.

In an update to a systematic review, we will summarise the evidence from cohort studies that have assessed study publication bias or outcome reporting bias in randomised controlled trials. Twenty-nine studies were eligible of which eleven were newly identified in this update. Eleven groups followed a cohort of trial through from protocol approval to information regarding publication of outcomes and investigated outcome reporting bias. Findings will be presented.

Guidelines for the content of statistical analysis plans in clinical trials were published in 2018. An analysis of 62 citations in early 2020 revealed a steady increase in the use of the guidance. Findings from an updated analysis of a further 168 citations by the end of 2023 will be presented.

The implications from contrasting the results from these two projects will be discussed.

Please note, you need to register for this event in order to receive an email invitation to join the session. Registrations are limited to 250 attendees and places will be offered on a first come first served basis.

This webinar will be hosted via MS Teams. You will need access to the web and sound facilities in order to view the webinar.

A recording of the webinar will be made available after the event. Previous recordings can be found here: https://www.methodologyhubs.mrc.ac.uk/about/webinar/

UKTMN members also have access to recordings via the UKTMN YouTube channel.

If you have any questions regarding this event or wish to cancel your place, please email uktmn@nottingham.ac.uk